| Subclassification of dilated cardiomyopathy and interferon treatment. | |
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MedLine Citation:
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PMID: 8682084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy-seven consecutive patients with dilated cardiomyopathy underwent left ventricular endomyocardial biopsy. In 20 biopsies (26%) enteroviral RNA was detected by in-situ hybridization. After an average observation period of more than 2 years only one patient had died in the enterovirus positive (ev+) group compared with 11 deaths and four heart transplantations in the enterovirus negative (ev-) group. After a mean follow-up of 16 +/- 9 months haemodynamic evaluation of the surviving ev+ patients showed significantly better results with respect to left ventricular ejection fraction and left ventricular end-diastolic diameter. The four ev+ patients with haemodynamic deterioration were given interferon-alpha, 3 million units subcutaneously every other day for six months. No severe side effects were seen and all four patients improved according to their haemodynamic and clinical parameters. In two of the four patients enteroviral RNA was not detectable in a subsequent biopsy. |
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Authors:
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M Stille-Siegener; A Heim; H R Figulla |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European heart journal Volume: 16 Suppl O ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-08-21 Completed Date: 1996-08-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 147-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Göttingen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathy, Dilated / classification*, diagnosis, mortality, therapy Coxsackievirus Infections / classification*, diagnosis, mortality, therapy Endocardium / pathology* Enterovirus B, Human* / drug effects Female Follow-Up Studies Heart Transplantation / mortality Hemodynamics / drug effects Humans Interferon Alfa-2a / therapeutic use* Male Middle Aged Myocardium / pathology* RNA, Viral / analysis Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/RNA, Viral; 76543-88-9/Interferon Alfa-2a |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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