| Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: pro-inflammatory antibodies in DCM patients. | |
| | |
MedLine Citation:
|
PMID: 10362496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Detection of antimyosin antibodies in non-inflammatory cardiac disease undermines their disease specificity as a sensitive marker of damage in dilated cardiomyopathy (DCM) patients. Antibody subclass specificity could provide a more sensitive marker of disease and possibly discriminate the humoral autoimmune responses in different cardiac diseases. Frequency and reactivity of autoantibodies against alpha- and beta-isoforms of myosin heavy chain (mhc) were evaluated by ELISA for IgG, IgM, and subclasses IgG1, IgG2, and IgG3 in patients with DCM (NYHA III/IV, n = 82), end stage ischemic heart disease (E-IHD: NYHA III/IV, n = 62), mild ischemic heart disease (NYHA I/II, n = 27), and controls (n = 54). Autoantibodies against atrial and ventricular myosin were raised in heart failure patients compared to mild-IHD and controls but with different antigen affinities. Reactivity in E-IHD was significantly raised against (ventricular) beta-mhc compared with only mild-IHD patients, suggesting a relative increase in ventricular specific antibodies in IHD patients with a higher NYHA class. IgG subclass analysis for IgG1, IgG2, and IgG3 against alpha- and beta-mhc showed statistically raised levels of IgG3 only in DCM patients and a significantly higher reactivity of IgG2 in heart failure patients versus controls. The results demonstrate immunological heterogeneity of antimyosin antibodies developed in different clinical entities. Pro-inflammatory characteristics of IgG3 antibodies in a select group of patients with DCM may contribute to autoimmune mechanisms of injury in these patients. |
| | |
Authors:
|
R S Warraich; M J Dunn; M H Yacoub |
Related Documents
:
|
6499626 - Immunological findings in whole and parotid saliva of patients with crohn's disease and... 21709556 - Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. 3508766 - Serum immunoglobulins in mycotic keratitis--an interim report. 548996 - Evidence of high polymeric iga levels in serum of patients with berger's disease and it... 8534716 - The identification of bone mineral density in capd in comparison with hd patients. 6101296 - Arrhythmia in hypertrophic cardiomyopathy: exercise and 48 hour ambulatory electrocardi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 259 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 1999-06-28 Completed Date: 1999-06-28 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 255-61 Citation Subset: IM |
Copyright Information:
|
Copyright 1999 Academic Press. |
Affiliation:
|
National Heart and Lung Institute, Harefield Hospital, Harefield, Middlesex, UB9 6JH, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Autoantibodies
/
classification,
immunology* Cardiomyopathy, Dilated / immunology* Female Humans Immunoglobulin G / classification, immunology Immunoglobulin M / immunology Immunoglobulins / classification, immunology Inflammation / immunology Male Middle Aged Myosin Heavy Chains / immunology Myosins / immunology* Protein Isoforms / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins; 0/Myosin Heavy Chains; 0/Protein Isoforms; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: M-type 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is the product of a late muscle differen...
Next Document: Characterization of a 3'-5' exonuclease associated with VDJP.