Document Detail

Subchronic treatment with imipramine ameliorates the decreased number in neuropeptide Y-positive cells in the hippocampus of learned helplessness rats.
MedLine Citation:
PMID:  15869748     Owner:  NLM     Status:  MEDLINE    
Learned helplessness, but not immobilization stress, decreased the numbers of neuropeptide Y (NPY)-positive cells (interneuron), but not calcitonin gene-related peptide (CGRP)-positive cells (mossy cell), in the hilus of the hippocampus. Subchronic treatment of learned helplessness rats, but not naive rats, with imipramine ameliorated the decrease in the number of NPY-positive cells. Therefore, NPY-positive cells in the hippocampus may contribute to depression.
Hisahito Ishida; Yukihiko Shirayama; Masaaki Iwata; Ryuzou Kawahara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain research     Volume:  1046     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-01     Completed Date:  2005-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Japan.
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MeSH Terms
Antidepressive Agents, Tricyclic / administration & dosage*
Calcitonin Gene-Related Peptide / metabolism
Cell Count
Drug Administration Schedule
Helplessness, Learned*
Hippocampus / cytology,  drug effects,  metabolism*
Imipramine / administration & dosage*
Interneurons / drug effects,  metabolism*
Neuropeptide Y / metabolism*
Rats, Sprague-Dawley
Restraint, Physical / physiology
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/Neuropeptide Y; 50-49-7/Imipramine; 83652-28-2/Calcitonin Gene-Related Peptide

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