Document Detail

Subchronic toxicological evaluation of brea gum (Parkinsonia preacox) as a food additive in BALB/c mice.
MedLine Citation:
PMID:  19793021     Owner:  NLM     Status:  MEDLINE    
Brea gum is a phloematic exudate from Parkinsonia praecox, an autoctonous tree that grows in the arid areas of Argentina. In this work, we propose its potential as a food additive. However, as no toxicological safety evaluation of brea gum has yet been reported, this preliminary study was conducted to evaluate its long-term toxicity over a 120-day period in BALB/c mice fed with brea gum at various levels in the diet. The results showed that animals on diets containing up to 5% brea gum were healthy, exhibiting growth curves similar to controls for both males (P = 0.9138) and females (P = 0.9459), thereby indicating that feed intake and utilization was not affected. A histopathological examination and weight recording of liver, kidneys, and intestine did not reveal any microscopic abnormalities or adverse toxicological effect (weights respect to control: P > 0.1). Moreover, hematological parameters and enzyme activities were within the normal values previously reported for mice. Our findings suggest that feeding brea gum at levels up to 5% to BALB/c mice do not exert any toxicological effects, supporting its potential use as a food additive for human consumption.
Axel R von M??ller; Cristina B L??pez; Aldo R Eynard; Carlos A Guzm??n
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  32     ISSN:  1525-6014     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-01     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Facultad de Ciencias Agropecuarias, Universidad Nacional de C??rdoba, C??rdoba, Argentina.
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MeSH Terms
Administration, Oral
Animal Feed
Antioxidants / administration & dosage,  toxicity*
Carcinogens / toxicity
Dietary Carbohydrates / administration & dosage,  adverse effects*
Fabaceae / chemistry
Food Additives / administration & dosage,  adverse effects*
Liver / drug effects
Models, Animal
Mutagenicity Tests
Organ Size
Plant Extracts / pharmacology
Plants, Genetically Modified
Polysaccharides / administration & dosage,  toxicity*
Reg. No./Substance:
0/Antioxidants; 0/Carcinogens; 0/Dietary Carbohydrates; 0/Food Additives; 0/Plant Extracts; 0/Polysaccharides

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