Document Detail

Subchronic toxicity study of urea molasses mineral block in kids.
MedLine Citation:
PMID:  18758984     Owner:  NLM     Status:  MEDLINE    
A study was conducted on twenty indigenous goat kids allocated into two different groups. All animals were offered ad libitum rice straw and berseem hay (40:60). Group I (T(1)) was fed concentrate mixture (100 g/d). Group II (T(2)) was supplemented with urea molasses mineral block (200 g/d). The experiment lasted for 90 days. There was significant decrease in serum sodium (60.68 mEq/L), increase in serum potassium (34.50 mEq/L) and increased activity of AST (340.42 U/L) and ALT (164.96 U/L) was observed in kids of group T(2) in comparison to the controls (T(1)). On histopathological examination mild degenerative changes in kidney of group T(2) with congestion in intertubular vessel, granular cytoplasm of the epithelial cells in PCT and DCT, necrosis and swelling of the epithelial cells, congestion of vessels and cloudy swelling was observed in PCT and DCT. Albuminious mass was also present in tubule. On histopathological observation of liver of kid of group T(2) oedema in liver parenchyma and proliferation of fibrious tissue in periportal area was observed.
Angan Roy; S P Tiwari; Kiran Kumari; M K Gendley; Rajan Gupta
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Publication Detail:
Type:  Journal Article     Date:  2008-08-30
Journal Detail:
Title:  Veterinary research communications     Volume:  33     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-04     Completed Date:  2009-07-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Department of Animal Nutrition, College of Veterinary Science and Animal Husbandry, Durg, Chhattisgarh, India.
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MeSH Terms
Alanine Transaminase / blood
Animal Feed
Aspartate Aminotransferases / blood
Chlorides / blood
Drug-Induced Liver Injury
Goat Diseases / chemically induced*,  metabolism
Histocytochemistry / veterinary
Kidney Diseases / chemically induced,  metabolism,  veterinary*
Liver Diseases / metabolism,  veterinary*
Molasses / toxicity*
Potassium / blood
Random Allocation
Sodium / blood
Urea / toxicity*
Reg. No./Substance:
0/Chlorides; 57-13-6/Urea; 7440-09-7/Potassium; 7440-23-5/Sodium; EC Aminotransferases; EC Transaminase

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