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Subchronic oral toxicity of evodia fruit powder in rats.
MedLine Citation:
PMID:  24384379     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used as a dietary supplement. However, information regarding its toxicity is limited.
MATERIALS AND METHODS: Evodia fruit from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (0, 25, 74, 222, 667, and 2,000mg/kg) was administered orally 5 times per week for 13 weeks. Clinical signs, body weight, food consumption, hematology, serum chemistry, urinalysis, vaginal cytology, sperm morphology, organ weight, and gross and histopathological findings were evaluated.
RESULTS: Urinary ketone body excretion was detected in males at 667 and 2,000mg/kg and in females at 2,000mg/kg. An increase in absolute/relative liver weight was observed in both sexes at 2,000mg/kg. Although levels of serum alanine aminotransferase, glucose, total cholesterol, and triglycerides were significantly reduced in males and/or females at 200 and/or 667 and 2,000mg/kg, all values were within normal ranges and were considered non-adverse. In addition, no treatment-related differences in body weight, food consumption, hematology, vaginal cytology, sperm morphology, or gross and histopathological examination were detected.
CONCLUSIONS: The subchronic no-observable-adverse-effect level for evodia fruit powder following oral administration in rats is greater than 2,000mg/kg.
Authors:
Duyeol Kim; Yong-Hoon Lee; Sun Hee Park; Mi Ju Lee; Myoung Jun Kim; Ho-Song Jang; Jung-Min Lee; Hye-Yeong Lee; Beom Seok Han; Woo-Chan Son; Ji Hyeon Seok; Jong Kwon Lee; Jayoung Jeong; Jin Seok Kang; Jong-Koo Kang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-30
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  -     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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