Document Detail

Subchronic feeding study of herbicide-tolerant soybean DP-356Ø43-5 in Sprague-Dawley rats.
MedLine Citation:
PMID:  18403083     Owner:  NLM     Status:  MEDLINE    
Optimum GAT1 soybean is a genetically modified (GM) soybean containing event DP-356Ø43-5 (356043) that was produced by integration of the coding sequences of the GAT4601 and GM-HRA proteins. In planta expression of these proteins confers tolerance to glyphosate and sulfonylurea/imidazolinone herbicides, respectively. This paper reports the results from a subchronic rat feeding study conducted with 356043 soybeans. Dehulled/defatted toasted meal and toasted ground hulls were prepared from soybeans from untreated plants (356043), herbicide-treated plants (356043+Gly/SU), non-transgenic isoline control (091), and three commercial non-transgenic reference varieties (93B86, 93B15, and 93M40). Individual diets conforming to standard certified rodent chow formulation (Purina Rodent LabDiet) 5002) were prepared with 20% meal (w/w) and 1.5% hulls (w/w). Diets were fed to young adult Sprague-Dawley rats (12/sex/group) for at least 93 days. Compared with rats fed the isoline control or conventional reference diets, no biologically-relevant, adverse effects were observed in rats fed diets containing 356043 or 356043+Gly/SU soybean with respect to body weight/gain, food consumption/efficiency, clinical signs, mortality, ophthalmology, neurobehavioral assessments (sensory response, grip strength, motor activity), clinical pathology (hematology, coagulation, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. The results from this study indicate that 356043 soybeans are as safe and nutritious as conventional non-GM soybeans.
Laura M Appenzeller; Susan M Munley; Denise Hoban; Greg P Sykes; Linda A Malley; Bryan Delaney
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Publication Detail:
Type:  Journal Article     Date:  2008-02-29
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2201-13     Citation Subset:  IM    
Pioneer Hi-Bred International, Inc., Johnston, IA, USA.
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MeSH Terms
Behavior, Animal / drug effects
Blood Cell Count
Blood Chemical Analysis
Blood Coagulation / drug effects
Body Weight / drug effects
Eating / drug effects
Eye Diseases / chemically induced,  pathology
Herbicides / toxicity*
Motor Activity / drug effects
Organ Size / drug effects
Plants, Genetically Modified / genetics*,  toxicity*
Psychomotor Performance / drug effects
Rats, Sprague-Dawley
Soybeans / genetics*,  toxicity*
Reg. No./Substance:

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