Document Detail

Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata.
MedLine Citation:
PMID:  17027936     Owner:  NLM     Status:  MEDLINE    
L-DOPA is the most effective pharmacological agent used for the symptomatic treatment of Parkinson's disease but long-term L-DOPA treatment induces involuntary abnormal movements such as dyskinesias. The present study, using in vivo microdialysis, investigated the effects of a single or subchronic administration of L-DOPA to adult rats with a unilateral 6-OHDA lesion of dopamine neurons on GABA release in the substantia nigra, pars reticulata (SNr). The results indicate that a challenge injection of L-DOPA (50 mg/kg, i.p.) significantly increases GABA levels in the SNr of rats treated with a daily repeated administration of L-DOPA (50 mg/kg, i.p.). Further statistical analysis between groups also showed that extracellular GABA levels were significantly higher in the subchronic L-DOPA group than in the group receiving only one injection of L-DOPA. These results show that the subchronic administration of L-DOPA results in a sensitization of enhanced extracellular GABA levels in the SNr.
Noriko Yamamoto; R Christopher Pierce; Jean-Jacques Soghomonian
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-10-09
Journal Detail:
Title:  Brain research     Volume:  1123     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-02-01     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  196-200     Citation Subset:  IM    
Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Room L1001, Boston, MA 02118, USA.
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MeSH Terms
Antiparkinson Agents / administration & dosage*,  adverse effects
Dopamine / metabolism
Dopamine Agents / administration & dosage,  adverse effects
Drug Administration Schedule
Levodopa / administration & dosage*,  adverse effects
Neurons / metabolism
Parkinsonian Disorders / chemically induced,  drug therapy*
Rats, Sprague-Dawley
Substantia Nigra / drug effects*,  secretion
gamma-Aminobutyric Acid / drug effects,  secretion*
Grant Support
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dopamine Agents; 0/Levodopa; 1199-18-4/Oxidopamine; 56-12-2/gamma-Aminobutyric Acid

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