| Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata. | |
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MedLine Citation:
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PMID: 17027936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-DOPA is the most effective pharmacological agent used for the symptomatic treatment of Parkinson's disease but long-term L-DOPA treatment induces involuntary abnormal movements such as dyskinesias. The present study, using in vivo microdialysis, investigated the effects of a single or subchronic administration of L-DOPA to adult rats with a unilateral 6-OHDA lesion of dopamine neurons on GABA release in the substantia nigra, pars reticulata (SNr). The results indicate that a challenge injection of L-DOPA (50 mg/kg, i.p.) significantly increases GABA levels in the SNr of rats treated with a daily repeated administration of L-DOPA (50 mg/kg, i.p.). Further statistical analysis between groups also showed that extracellular GABA levels were significantly higher in the subchronic L-DOPA group than in the group receiving only one injection of L-DOPA. These results show that the subchronic administration of L-DOPA results in a sensitization of enhanced extracellular GABA levels in the SNr. |
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Authors:
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Noriko Yamamoto; R Christopher Pierce; Jean-Jacques Soghomonian |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-10-09 |
Journal Detail:
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Title: Brain research Volume: 1123 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-02-01 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 196-200 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Room L1001, Boston, MA 02118, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiparkinson Agents / administration & dosage*, adverse effects Dopamine / metabolism Dopamine Agents / administration & dosage, adverse effects Drug Administration Schedule Levodopa / administration & dosage*, adverse effects Male Microdialysis Neurons / metabolism Oxidopamine Parkinsonian Disorders / chemically induced, drug therapy* Rats Rats, Sprague-Dawley Substantia Nigra / drug effects*, secretion gamma-Aminobutyric Acid / drug effects, secretion* |
| Grant Support | |
ID/Acronym/Agency:
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NS40783/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Dopamine Agents; 0/Levodopa; 1199-18-4/Oxidopamine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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