Document Detail


Subchronic (90-day) toxicity study in rats fed gum kondagogu (Cochlospermumgossypium).
MedLine Citation:
PMID:  10828504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although gum kondagogu (Cochlospermum gossypium) is grouped under gum karaya (Sterculia sp.), it differs significantly in terms of physicochemical properties and chemical composition and does not conform to the confirmatory tests prescribed for gum karaya ([Janaki]). Gum karaya has wide applications in the pharmaceutical and food industries, whereas the use of gum kondagogu is yet to be explored. In this context, a short-term toxicity study on gum kondagogu was undertaken in rats. The gum was fed to rats at 0, 0.2%, 1% and 5% (w/w) in feed, for 90 days. Biochemical parameters were measured to assess the toxicity at the end of the study period. The results indicated no significant changes in growth pattern, haematological indices (RBC, WBC, Hb, PCV, MCV, MCH, MCHC, differential leucocyte counts), biochemical analytes (glucose, urea nitrogen, total protein, albumin, bilirubin, creatinine, sodium and potassium ions), activities of plasma and liver enzymes (alkaline phosphatase, alanine amino-transaminase, aspartate aminotransaminase, lactate dehydrogenase, glutathione S-transferase and gamma-glutamyl transpeptidases and organ to body mass ratio (brain, heart, lungs, liver, kidneys and spleen). Histopathology of the liver and kidney also did not reveal any abnormality. An increased faecal bulk was observed in rats fed with 5% gum kondagogu. However, faecal moisture content of female rats only was significantly different (P=<0.05) as compared to controls. Thus, it can be inferred, based on the present investigations, that gum kondagogu has a potential application as a food additive, similar to gum karaya. Feeding it at a much higher level (5%) than expected for consumption as a food additive also did not result in any toxic effect. Being non-toxic, gum kondagogu has a potential as a food additive with excellent physicochemical properties and a unique chemical composition.
Authors:
B Janaki; R B Sashidhar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  38     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  523-34     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University College of Science, Osmania University, Hyderabad, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Female
Food Additives / toxicity
Liver / cytology,  drug effects
Male
Malvaceae / chemistry*
Organ Size / drug effects
Plant Extracts / metabolism,  toxicity
Polysaccharides / toxicity*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Food Additives; 0/Plant Extracts; 0/Polysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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