| Subchromosomal DNA synthesis in synchronous V-79 chinese hamster cells after X irradiation. | |
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MedLine Citation:
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PMID: 6494439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A substantial fraction of replicon initiation events in Chinese hamster V-79 cells have been shown to be refractory to the effects of X irradiation immediately after exposure. This study examines the possibility that the initiation radiorefractive portion is the result of changes in replicon radiosensitivity as a function of position in S phase. The data obtained from DNA fiber autoradiograms and kinetic incorporation of radiolabeled thymidine from cells irradiated at various positions in S phase showed only slight changes in the proportion of replicons refractive to X irradiation immediately after exposure. These results indicate that initiation radiorefractive replicons may be an intrinsic property of V-79 cells and that cell-cycle-specific heterogeneity in radiation response cannot fully account for this phenomenon. The results also indicate that delayed inhibition of initiation events may play a larger role in the observed radiorefractive fraction than previously thought. |
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Authors:
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P J Meechan; J G Carpenter; T D Griffiths |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiation research Volume: 100 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1984-12-18 Completed Date: 1984-12-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-81 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cell Line Cell Survival / radiation effects Cricetinae Cricetulus DNA / biosynthesis* Dose-Response Relationship, Radiation Interphase / radiation effects* Replicon / radiation effects* |
| Grant Support | |
ID/Acronym/Agency:
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AG-03415/AG/NIA NIH HHS; CA-32579/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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