Document Detail


Subcellular localization of beta-catenin and cadherin expression in the cap-stage enamel organ of the mouse molar.
MedLine Citation:
PMID:  14997319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed the subcellular distribution of beta-catenin in the cap-stage enamel organ and compared it with the expression of E- and P-cadherin by using confocal laser microscopy. The amounts of the molecules in the cytoplasm and the nucleus showed regional variations in the enamel organ, whereas cell surface-associated beta-catenin was ubiquitous. In both the enamel knot and the inner dental epithelium, beta-catenin was detected in the cytoplasm and in the nucleus. However, the amount of nuclear beta-catenin was apparently higher in the enamel knot than in the inner dental epithelium. P-cadherin also gave a stronger signal in the enamel knot than in other parts of the enamel organ. In the stellate reticulum, where E-cadherin was preferentially expressed, as well as in the cervical loop and outer dental epithelium, beta-catenin was localized in the cytoplasm but not in the nucleus. The nuclear localization of beta-catenin in the enamel knot suggests a specific activation of the canonical Wnt signaling pathway. A coincident upregulation of P-cadherin was observed in this area. Altogether, these observations suggest the possibility of a linkage between cell adhesion and Wnt signaling in the enamel knot.
Authors:
Nobuko Obara; Hervé Lesot
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Publication Detail:
Type:  Journal Article     Date:  2004-03-02
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  121     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2005-01-31     Revised Date:  2005-11-21    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  351-8     Citation Subset:  IM    
Affiliation:
Department of Oral Anatomy, School of Dentistry, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 061-0293, Hokkaido, Japan. obara@hoku-iryo-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cadherins / metabolism*
Cell Adhesion
Cytoskeletal Proteins / metabolism*
Enamel Organ / metabolism*
Intercellular Signaling Peptides and Proteins / metabolism
Mice
Molar / metabolism*
Signal Transduction
Tissue Distribution
Trans-Activators / metabolism*
Up-Regulation
Wnt Proteins
beta Catenin
Chemical
Reg. No./Substance:
0/Cadherins; 0/Catnb protein, mouse; 0/Cytoskeletal Proteins; 0/Fath protein, mouse; 0/Intercellular Signaling Peptides and Proteins; 0/Trans-Activators; 0/Wnt Proteins; 0/beta Catenin

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