Document Detail

Subcellular distribution of tetrodotoxin in puffer fish liver.
MedLine Citation:
PMID:  10519659     Owner:  NLM     Status:  MEDLINE    
The liver homogenate of puffer fish was fractionated into blood cell, nuclear, mitochondrial, microsomal and cytosol fractions by the differential centrifugation method. All the five fractions were toxic to mice, although the toxin amount was significantly high in the cytosol fraction. Analyses by HPLC and LC-FABMS demonstrated that tetrodotoxin is the major toxic principle in each fraction. These results reveal that tetrodotoxin is widely distributed in organelles in liver cells, though predominantly in the cytosol fraction.
Y Nagashima; Y Hamada; H Ushio; S Nishio; K Shimakura; K Shiomi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  37     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-10-28     Completed Date:  1999-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1833-7     Citation Subset:  IM    
Department of Food Science and Technology, Tokyo University of Fisheries, Minato, Japan.
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MeSH Terms
Chromatography, High Pressure Liquid
Cytosol / metabolism
Fishes, Poisonous*
Liver / cytology,  metabolism*
Spectrometry, Mass, Fast Atom Bombardment
Subcellular Fractions / metabolism
Survival Rate
Tetrodotoxin / pharmacokinetics*,  toxicity
Tissue Distribution
Toxicity Tests
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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