Document Detail

Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens.
MedLine Citation:
PMID:  23143514     Owner:  NLM     Status:  MEDLINE    
We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output.
Andrew F MacAskill; Justin P Little; John M Cassel; Adam G Carter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-11
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2013-01-29     Revised Date:  2014-04-17    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1624-6     Citation Subset:  IM    
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MeSH Terms
Action Potentials / physiology*
Animals, Newborn
Neural Pathways / cytology,  physiology
Nucleus Accumbens / cytology*,  physiology*
Organ Culture Techniques
Signal Transduction / physiology*
Subcellular Fractions / physiology
Grant Support
092200//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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