Document Detail

Subatmospheric closing pressures in individual microvessels of rats and frogs.
MedLine Citation:
PMID:  7602519     Owner:  NLM     Status:  MEDLINE    
1. We have investigated the hypothesis that ascending vasa recta (AVR) in the rat renal medulla are able to remain open when the external pressure is greater than the internal. 2. Individual vasa recta were cannulated in anaesthetized rats with Evans Blue albumin solution and then occluded downstream prior to the first branchpoint. When the intraluminal pressure was lowered, the lumina collapsed at a mean pressure of approximately -4.0 cmH2O for both AVR and descending vasa recta. 3. The studies were extended to include microvessels from rat spinotrapezius muscle and mesentery and frog mesentery; mean closing pressures were -3.2, -4.2 and -5.3 cmH2O, respectively. 4. Subatmospheric closing pressures may allow small differences in hydrostatic pressure alone to drive fluid uptake into the AVR.
P J MacPhee; C C Michel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  484 ( Pt 1)     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Department of Physiology and Biophysics, St Mary's Hospital Medical School, Imperial College of Science, Norfolk Place, London, UK.
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MeSH Terms
Arterioles / physiology
Evans Blue
Hydrostatic Pressure
Kidney Medulla / blood supply*,  physiology
Mesentery / blood supply,  physiology
Microcirculation / physiology
Muscles / blood supply,  physiology
Rana temporaria
Rats, Sprague-Dawley
Venules / physiology
Grant Support
//Wellcome Trust
Reg. No./Substance:
314-13-6/Evans Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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