Document Detail


Subarachnoid placement of stem cells in neurological disorders.
MedLine Citation:
PMID:  18555135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: "Medically untreatable neurological disorders" is an area where stem cell (SC) therapy has generated hope in the last decade. Among various routes for SC infusion, subarachnoid placement via the lumbar route is particularly challenging because of technical difficulties in this group of patients. We carried out a prospective, single-center, clinical study to analyze the technical difficulties and short- and long-term effects of SC infusion in various neurological conditions. PATIENTS AND METHODS: One hundred eighty patients underwent subarachnoid placement of SCs between December 2005 and October 2007. Technical difficulties in the form of localization of subarachnoid space, number of attempts, and postprocedural complications were evaluated. Functional evaluation was done with Hauser Ambulation Index by the SC transplant team on a regular basis. The Institutional Review Board approved of informed consent forms and study protocol. RESULTS: Of 180 patients, we encountered technical difficulties in 52 (29%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. In 102 (56.6%) patients, side effects were observed (headache, low-grade fever, and meningism), which resolved with symptomatic treatment within 24 hours. On long-term follow-up, functional indices improved in 57 (31.67%) patients, including 54 patients with traumatic paraplegia/quadriplegia, two with cerebral palsy, and one with viral encephalitis. CONCLUSION: Subarachnoid placement of SCs is safe with no long term adverse effects.
Authors:
T Mehta; A Feroz; U Thakkar; A Vanikar; V Shah; H Trivedi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  40     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-08-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1145-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology and Critical Care, Dr H.L. Trivedi Institute of Transplantation Sciences (ITS)-G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC), Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India.
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MeSH Terms
Descriptor/Qualifier:
Brain Diseases / surgery
Humans
Motor Neuron Disease / surgery
Safety
Spinal Cord Injuries / surgery*
Stem Cell Transplantation / adverse effects,  methods*
Subarachnoid Space / surgery*

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