Document Detail

Subarachnoid hemorrhage and the heart.
MedLine Citation:
PMID:  3511399     Owner:  NLM     Status:  MEDLINE    
Electrocardiographic abnormalities, both morphological and rhythmic, are frequently seen in association with spontaneous subarachnoid hemorrhage. These changes, which often reflect subendocardial damage, seem to be caused by hypothalamic stimulation leading to an acute increase in sympathetic tone. As a result, potentially life-threatening ventricular arrhythmias may develop in subarachnoid hemorrhage patients. These arrhythmias have responded to sympathetic blocking agents, which may also have a protective effect on subendocardial tissue in this setting. There is no evidence that the prophylactic administration of propranolol or other autonomic blockers significantly alters outcome in these patients. Ultimate morbidity and mortality are clearly related to the degree of intracerebral-intraventricular hemorrhage and vasospasm. This article reviews experimental and clinical evidence regarding the causes of cardiac abnormalities after subarachnoid hemorrhage, the types of abnormalities most frequently seen, their relationship with subendocardial lesions, and the role of autonomic blockers.
D W Marion; R Segal; M E Thompson
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Publication Detail:
Type:  Bibliography; Case Reports; Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  18     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-06     Completed Date:  1986-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-6     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / drug therapy,  etiology*
Bibliography as Topic*
Catecholamines / blood
Coronary Disease / etiology
Endocardium / pathology
Heart Ventricles / pathology
Hemorrhage / etiology
Hypothalamus / physiopathology
Myocardium / enzymology
Phentolamine / therapeutic use
Propranolol / therapeutic use
Subarachnoid Hemorrhage / complications*
Reg. No./Substance:
0/Catecholamines; 50-60-2/Phentolamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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