| Subarachnoid blood infusion versus raised intracranial pressure: effects on the amino acid pattern in the extracellular fluid of the rabbit hippocampus. | |
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MedLine Citation:
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PMID: 10406014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the role of a hemorrhage versus that of a transient increase in intracranial pressure in subarachnoid hemorrhage, the two components were induced separately in rabbits. Extracellular glutamate, sampled from the hippocampus with microdialysis, was used to evaluate the degree of CNS tissue damage. In four rabbits, autologous arterial blood was infused in the cisterna magna in a volume that would not affect the intracranial pressure. The other group of animals was infused with saline to elevate the intracranial pressure from 10 to > 100 mmHg. The increase of intracranial pressure per se did not induce significant changes in extracellular glutamate. However, 20-60 min after infusion of blood, a significant glutamate increase was recorded. Furthermore, aspartate, alanine, glycine and serine were also raised. The results indicate that blood in the subarachnoid space damages the brain primarily by inducing ischemia. Furthermore, the parameters employed gave no indication that an increase in intracranial pressure had a deleterious effect on CNS tissue. |
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Authors:
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M Runnerstam; H Stephensen; C von Essen; B Nyström; A Hamberger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 21 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 404-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood* Animals Blood Gas Analysis Blood Pressure / physiology Blood Transfusion, Autologous Chromatography, Liquid / methods Extracellular Space / metabolism* Hippocampus / metabolism* Infusions, Intra-Arterial Intracranial Pressure / physiology* Microdialysis Rabbits Subarachnoid Space |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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