Document Detail


Subacute thrombosis and vascular injury resulting from slotted-tube nitinol and stainless steel stents in a rabbit carotid artery model.
MedLine Citation:
PMID:  8840868     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Our objectives were to quantify the thrombogenicity and extent of vascular injury created by slotted-tube geometry stainless steel and nitinol coronary stents in a rabbit carotid artery model. METHODS AND RESULTS: Stents were implanted in rabbit right carotid arteries without antiplatelet therapy. Stainless steel stents were implanted for 4 days while nitinol stents were placed for 4 and 14 days (n = 8, 8, and 6, respectively). Stent thrombosis was assessed by thrombus weight, grading thrombus encroachment of the lumen, and by blood flow in the stented and contralateral arteries. Stainless steel stents at 4 days contained more thrombus than 4- and 14-day nitinol stents (20.0 +/- 5.9 versus 2.5 +/- 0.6 and 2.7 +/- 0.3 mg, respectively; P < .000001). Stainless steel stents were more often occluded by thrombus (6 of 8) or contained more subocclusive thrombus (2 of 8) than nitinol stents (0 of 14, P < .002). Resting blood flow was reduced in arteries with stainless steel stents compared with 4- and 14-day nitinol stents (1.5 +/- 2.8 versus 24.0 +/- 2.0 and 25.5 +/- 1.9 mL/min, respectively, P < .000001). Stainless steel stents were less uniformly expanded, had deeper strut penetration into the vascular wall, and were associated with more extensive medial smooth muscle cell necrosis. There were strong correlations (r = .77 to .95) between variables of thrombosis extent (thrombus weight and grade) and histologically determined vascular injury (strut penetration and medial necrosis). CONCLUSIONS: Slotted-tube stainless steel stents were more thrombogenic and created more extensive vascular injury than nitinol stents in a rabbit carotid artery model. The mechanisms underlying these differences probably are related to metallurgic and design geometry properties of the two stent types.
Authors:
S Sheth; F Litvack; V Dev; M C Fishbein; J S Forrester; N Eigler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  94     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-29     Completed Date:  1996-11-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1733-40     Citation Subset:  AIM; IM    
Affiliation:
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Alloys*
Animals
Carotid Arteries / pathology
Carotid Artery Injuries*
Carotid Artery Thrombosis / etiology*,  pathology
Equipment Design
Male
Microscopy, Electron, Scanning
Necrosis
Rabbits
Stainless Steel*
Stents / adverse effects*
Tunica Media / pathology
Wounds and Injuries / etiology
Grant Support
ID/Acronym/Agency:
R01-HL-53226/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Alloys; 12597-68-1/Stainless Steel; 52013-44-2/nitinol
Comments/Corrections
Erratum In:
Circulation 1996 Nov 15;94(10):2668

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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