Document Detail


Subacute stent thrombosis owing to complete clopidogrel resistance successfully managed with prasugrel.
MedLine Citation:
PMID:  21725128     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This report describes a case of an acute anterior myocardial infarction secondary to subacute stent thrombosis of a drug-eluting stent within the proximal segment of the left anterior descending artery (LAD) 5 days after percutaneous transluminal coronary angioplasty and stenting (PCI). The patient was initially managed with conventional dual-antiplatelet therapy (aspirin and clopidogrel) and was subsequently found to have complete absence of adenosine diphosphate (ADP) receptor P2Y12 receptor inhibition. Following additional PCI of the LAD and substitution of clopidogrel for the thienopyridine prasugrel, therapeutic platelet inhibition was achieved without recurrence of stent thrombosis.
Authors:
Michael P Flaherty; Peter V Johnston; Jeffrey J Rade
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  23     ISSN:  1557-2501     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Affiliation:
The Johns Hopkins School of Medicine, Division of Cardiology, Blalock 524 - Room 501, 600 North Wolfe Street, Baltimore, MD 21287 USA. jjrade@jhmi.edu.
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