Document Detail

Subacute spongiform encephalopathies.
MedLine Citation:
PMID:  16340337     Owner:  NLM     Status:  MEDLINE    
Subacute spongiform encephalopathies are rare fatal diseases that affect the central nervous system, which is thought to be caused by prions, characterized clinically by a rapid progressive dementing course, along with generalized myoclonus. The prototype of these conditions in humans is Creutzfeldt-Jakob Disease (CJD). Although the final diagnosis depends on neuropathological examination, the presence of periodic sharp wave complexes on EEG and of the neuron-specific enolase, tau protein, S-100, and of the 14-3-3 protein in the cerebrospinal fluid, make the diagnosis of probable CJD. However, as these criteria are not completely accurate and the early diagnosis is extremely difficult, much interest has been focused recently on imaging methods. With the advent of diffusion-weighted imaging, MRI has shown high sensitivity and specificity, therefore being considered a useful method for the early diagnosis of this entity.
Renato A Mendon?a; Giovanna Martins; Ricardo Lugokenski; Marcelo D'Andrea Rossi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Topics in magnetic resonance imaging : TMRI     Volume:  16     ISSN:  0899-3459     ISO Abbreviation:  Top Magn Reson Imaging     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913523     Medline TA:  Top Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
MedImagem, Hospital S?o Joaquim, Real e Benem?rita Associa??o Portuguesa de Benefic?ncia, S?o Paulo, Brasil.
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MeSH Terms
Creutzfeldt-Jakob Syndrome / cerebrospinal fluid,  diagnosis*
Diagnosis, Differential
Magnetic Resonance Imaging / methods*
Sensitivity and Specificity

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