Document Detail

Subacute neurotoxicity of 5-fluorouracil and its derivative, carmofur, in cats.
MedLine Citation:
PMID:  3218507     Owner:  NLM     Status:  MEDLINE    
The subacute neurotoxicity of 5-fluorouracil (FU) and its derivative, carmofur (HCFU), in cats was morphologically examined; both these drugs were orally administered once daily for a maximum of three months. The dosis of FU and HCFU was 2 mg/kg/day and 10 mg/kg/day, respectively. Both FU and HCFU induced two sorts of changes in the brain, i.e., vacuolation and softening-like change. The former was distributed in the white matter of the cerebrum and cerebellum and in areas of the gray matter such as the tectum and tegmentum of the brain stem, while the latter was distributed exclusively in the gray matter of the tectum and tegmentum of the brain stem. The tectum, especially the inferior colliculus, was most frequently affected by both types of change. Ultrastructurally, vacuolation was found to be due to lamellar splitting or separation between the axon and innermost myelin layer. These findings were compared with those in dogs and as the etiopathogenesis vacuolation due to direct toxic effect of FU or its metabolites to myelin and softening-like change due to local circulatory disturbance caused by vacuolation were proposed.
R Okeda; M Shibutani; T Matsuo; T Kuroiwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  38     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-03-06     Completed Date:  1989-03-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1255-66     Citation Subset:  IM    
Department of Pathology, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Behavior, Animal / drug effects
Cerebellum / drug effects,  ultrastructure
Fluorouracil / analogs & derivatives*,  pharmacology,  toxicity*
Microscopy, Electron
Neurons / drug effects,  ultrastructure
Neurotoxins / toxicity*
Reg. No./Substance:
0/Neurotoxins; 51-21-8/Fluorouracil; 61422-45-5/1-hexylcarbamoyl-5-fluorouracil

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