Document Detail

Subacute necrotizing encephalopathy in a pig-tailed macaque (Macaca nemestrina) that resembles mitochondrial encephalopathy in humans.
MedLine Citation:
PMID:  15357324     Owner:  NLM     Status:  MEDLINE    
A male pig-tailed macaque (Macaca nemestrina), approximately 5 years old, was found to be vision-impaired and to have profound behavioral abnormalities, including hyperactivity and self-injurious behavior that was not amenable to amelioration by environmental enrichment. Facial and skeletal dysmorphisms also were noted. Magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning revealed areas of possible infarction in the occipital lobes and megaventriculosis. At necropsy, following euthanasia for humane reasons, severe polio- and leukoencephalomalacia accompanied by megaventriculosis were seen in both occipital lobes and in several sulci of the parietal and frontal lobes. Light microscopic findings included loss of neocortical structure, with necrosis, neuronal loss, astrogliosis, vascular proliferation, mild spongiosis, and demyelination. The extent and severity of lesions were most pronounced in the occipital lobes and were greater in the left than in the right hemisphere. Other lesions included mild bilateral atrophy of the optic nerves, thymic involution, necrotizing dermatitis due to trauma, and a spectrum of spermatozoal abnormalities. The imaging and gross and light microscopic changes found in this animal resemble the mitochondrial encephalopathies of humans; this was corroborated by results of immunohistochemical analysis demonstrating decreased expression of enzymes of the mitochondrial oxidative complex ([OC]-I, -III, and -IV) in brain and muscle, and detection of fibrinogen immunoreactivity in neurons and glial cells. The spermatozoal defects may represent yet another aspect of a mitochondrial defect.
Helle Bielefeldt-Ohmann; Rita U Bellanca; Carolyn M Crockett; Eliza Curnow; Kathy Eiffert; Maggie Gillen; Debra Glanister; Eric Hayes; Stephen Kelley; Satoshi Minoshima; Keith Vogel
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Comparative medicine     Volume:  54     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2005-08-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-33     Citation Subset:  IM    
Washington National Primate Research Center, University of Washington, Seattle, Washington 98195-7330, USA.
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MeSH Terms
Animals, Laboratory
Behavior, Animal / physiology
Brain / pathology,  physiopathology
Leigh Disease / pathology,  physiopathology,  veterinary*
Macaca nemestrina*
Mitochondria / chemistry,  metabolism
Mitochondrial Encephalomyopathies / pathology,  physiopathology,  veterinary*
Monkey Diseases* / pathology,  physiopathology
Spermatozoa / abnormalities,  metabolism
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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