Document Detail

Sub-clinical left ventricular diastolic dysfunction in early stage of chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  22023769     Owner:  NLM     Status:  In-Data-Review    
Sub-clinical cardiac dysfunction may be significantly associated with chronic obstructive pulmonary disease (COPD) with a different degree of severity. In a cross-sectional design we aimed to evaluate the frequency of left ventricular diastolic dysfunction (LVdd) and its correlation with lung function, pulmonary arterial pressure and systemic inflammation in a selected population of COPD at an early stage of their disease. Fifty-five COPD patients with no clinical signs of cardiovascular dysfunction were recruited and compared to 40 matched healthy controls. All the subjects underwent pulmonary function testing, doppler echocardiography, and interleukin-6 blood sampling. Presence of LVdd was defined according to the significant change in both the ratio between early and late diastolic transmitral flow velocity (E/A ratio), isovolumetric relaxation time (IVRT), and deceleration time (DT). The frequency of LVdd was higher in the COPD group (70.9 percent) compared to controls (27.5 percent). In these patients decreased E/A ratio, and prolonged IVRT and DT clearly pointed to left ventricular filling impairment, a condition we found to be especially severe in those patients suffering from lung static hyperinflation as expressed by inspiratory-to-total lung capacity ratio (IC/TLC) <0.25. Circulating levels of interleukin-6 were also higher among COPD patients compared to controls. The results of the present study suggest that subclinical left ventricular filling impairment is frequently found in COPD patients at the earlier stage of the disease even in the absence of any other cardiovascular dysfunction. Doppler echocardiography may help the early identification of LVdd in COPD patients.
M Malerba; B Ragnoli; M Salameh; G Sennino; M L Sorlini; A Radaeli; E Clini
Related Documents :
16765679 - Family history of inflammatory bowel disease in patients with idiopathic ocular inflamm...
6379849 - The o.m.g.e. multinational inflammatory bowel disease survey 1976-1982. a further repor...
16981069 - Clinical course of collagenous colitis over a period of 10 years.
17592319 - Fluorescein dye improves microscopic evaluation and counting of demodex in blepharitis ...
453729 - Colitis and pseudomembranous colitis associated with cephazolin prophylaxis.
20428899 - The presence of fistulas and nod2 homozygosity strongly predict intestinal stenosis in ...
14610129 - Diminished nocturnal lipolysis in cluster headache: a sign of central sympathetic dysre...
17689389 - Cerebral microbleeds and intracerebral hemorrhages in patients on maintenance hemodialy...
18612439 - Statins improve human coronary atherosclerotic plaque morphology.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  25     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  443-51     Citation Subset:  IM    
Department of Internal Medicine, University of Brescia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lycopene and preclinical carotid atherosclerosis.
Next Document:  Cytology and clinical spectrum of sexually transmitted infections in Lebanese women as revealed by p...