| Sub-chronic effects of nitrate in drinking water on red-legged partridge (Alectoris rufa): oxidative stress and T-cell mediated immune function. | |
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MedLine Citation:
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PMID: 20382380 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to evaluate the effects of nitrates on birds, we have exposed captive red-legged partridges to nitrates concentrations of 0 (control), 100 (dwell water in farming areas) or 500 mg/l (fertirrigation level). The cellular immune response, plasma biochemistry, methemoglobin concentration (metHb), and oxidative stress biomarkers in blood and tissues were studied after two weeks of exposure. Several blood parameters such as aspartate aminotransferase, creatinine phosphokinase and lactate dehydrogenase activities and magnesium level decreased with nitrate exposure, whereas alkaline phosphatase activity and creatinine level increased. The oxidant effect of nitrates was evidenced by the increase in blood metHb, accompanied by the lipid peroxidation of red blood cells, the increased levels of oxidized glutathione (GSH) in liver, and the generation of oxidative DNA damage in plasma lymphocytes. GSH in erythrocytes was negatively correlated with blood metHb. The cellular immune function was slightly lower at partridges exposed to nitrates. These results suggest that adverse effects of nitrates on birds occur at concentrations potentially present in the field. |
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Authors:
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Jaime Rodríguez-Estival; Mónica Martínez-Haro; M A Paz Martín-Hernando; Rafael Mateo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-10 |
Journal Detail:
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Title: Environmental research Volume: 110 ISSN: 1096-0953 ISO Abbreviation: Environ. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0147621 Medline TA: Environ Res Country: United States |
Other Details:
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Languages: eng Pagination: 469-75 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo s/n, 13071 Ciudad Real, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / blood Comet Assay DNA Damage Dose-Response Relationship, Drug Drinking Female Galliformes / immunology*, metabolism Immunity, Cellular / drug effects Liver / metabolism Methemoglobin / metabolism Nitrates / administration & dosage, toxicity* Oxidative Stress* T-Lymphocytes / drug effects* Tocopherols / blood, metabolism Vitamin A / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrates; 11103-57-4/Vitamin A; 1406-66-2/Tocopherols; 9008-37-1/Methemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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