Document Detail

Sub-Tenon's block: the effect of hyaluronidase on speed of onset and block quality.
MedLine Citation:
PMID:  10212716     Owner:  NLM     Status:  MEDLINE    
The role of hyaluronidase on the onset time and quality of single quadrant sub-Tenon's block was studied in a prospective, randomized, double-blind controlled manner. One hundred and twenty consecutive patients undergoing cataract surgery under local anaesthesia received a sub-Tenon's block with either of two local anaesthetic solutions. One consisted of 2% plain lignocaine 3 ml with 0.5% plain bupivacaine 2 ml. The other consisted of 2% lignocaine 1 ml containing 150 i.u. per ml of hyaluronidase with 2% plain lignocaine 2 ml and 0.5% plain bupivacaine 2 ml. The development of akinesia and the resulting block quality were assessed. Akinesia scores were lower at all time intervals and were significantly lower (P < 0.05) up to 9 minutes after block in the hyaluronidase group. However, block quality as assessed by the surgeon was not significantly different between the groups. The addition of 150 IU hyaluronidase significantly speeds up the onset of surgical anaesthesia produced by a sub-Tenon's block.
P Guise; S Laurent
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  27     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-16     Completed Date:  1999-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  IM    
Department of Anaesthesia, Auckland Hospital, New Zealand.
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MeSH Terms
Anesthetics, Local / administration & dosage
Bupivacaine / administration & dosage
Cataract Extraction*
Double-Blind Method
Hyaluronoglucosaminidase / administration & dosage*
Lidocaine / administration & dosage
Neuromuscular Blockade*
Time Factors
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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