| Styrene metabolism and striatal dopamine depletion in rabbits. | |
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MedLine Citation:
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PMID: 2869748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The striatal concentration of dopamine (DA), norepinephrine (NE), and homovanillic acid (HVA) was assessed in adult male rabbits exposed to styrene vapours or dosed with mandelic acid (MA), phenylglyoxylic acid (PGA) and phenylglycine (PG). Styrene exposure produced a marked and dose-dependent decrease in striatal DA, concomitant with a consistent increase in HVA. The same effects were caused by i.p. administration of PGA and PG, but not of MA. The increased catabolism of DA was concomitant with a normal turnover time after inhibition of tyrosine hydroxylase by the administration of methyl-p-tyrosine. The amination of PGA to PG with a subsequent competition of the latter with DA for the vesicular storage capacity is suggested as the possible mechanism for styrene-induced brain dysfunction. |
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Authors:
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A Mutti; A Romanelli; M Falzoi; S Lucertini; I Franchini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement Volume: 8 ISSN: 0171-9750 ISO Abbreviation: Arch. Toxicol. Suppl. Publication Date: 1985 |
Date Detail:
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Created Date: 1986-04-10 Completed Date: 1986-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802567 Medline TA: Arch Toxicol Suppl Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 447-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / analysis*, drug effects Dopamine / analysis* Glycine / analogs & derivatives, pharmacology Glyoxylates / pharmacology Homovanillic Acid / analysis Male Mandelic Acids / pharmacology Nervous System Diseases / chemically induced Norepinephrine / analysis Rabbits Styrene Styrenes / metabolism*, pharmacology, toxicity Tyrosine 3-Monooxygenase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glyoxylates; 0/Mandelic Acids; 0/Styrenes; 100-42-5/Styrene; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine; 56-40-6/Glycine; 611-73-4/phenylglyoxylic acid; 69-91-0/2-phenylglycine; 90-64-2/mandelic acid; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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