Document Detail


Stuttering interneurons generate fast and robust inhibition onto projection neurons with low capacity of short term modulation in mouse lateral amygdala.
MedLine Citation:
PMID:  23527307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The stuttering interneurons (STi) represent one minor subset of interneuron population and exhibit characteristic stuttering firing upon depolarization current injection. While it has been long held that the GABAergic inhibitory transmission largely varies with the subtype identity of presynaptic interneurons, whether such a rule also applies to STi is largely unknown. Here, by paired recording of interneuron and their neighboring projection neuron in lateral amygdala, we found that relative to the fast spiking and late spiking interneurons, the STi-evoked unitary postsynaptic currents onto the projection neurons had markedly larger amplitude, shorter onset latency and faster rising and decay kinetics. The quantal content and the number of vesicles in the readily releasable pool were also larger in synapses made by STi versus other interneurons. Moreover, the short-term plasticity, as reflected by the paired pulse depression and depolarization-induced suppression of inhibition, was the least prominent in the output synapses of STi. Thus, the fast and robust inhibition together with its low capacity of short term modulation may suggest an important role for STi in preventing the overexcitation of the projection neurons and thus gating the information traffic in amygdala.
Authors:
Chen Song; Xiao-Bin Xu; Ye He; Zhi-Peng Liu; Min Wang; Xin Zhang; Bao-Ming Li; Bing-Xing Pan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-03-19
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-09-17     Revised Date:  2014-03-04    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e60154     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amygdala / cytology*,  physiology
Analysis of Variance
Animals
Fluorescence
Histological Techniques
Interneurons / physiology*
Male
Mice
Patch-Clamp Techniques
Synaptic Potentials / physiology*
Synaptic Transmission / physiology*
Synaptic Vesicles / physiology
Comments/Corrections
Erratum In:
PLoS One. 2013;8(6). doi:10.1371/annotation/3bc30ead-f84a-434a-8314-4aa1c9fcdcc0

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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