Document Detail

Studying the emergence of autism spectrum disorders in high-risk infants: methodological and practical issues.
MedLine Citation:
PMID:  16897376     Owner:  NLM     Status:  MEDLINE    
Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective studies of young children at high-risk for autism, there are also significant methodological, ethical and practical challenges. This paper outlines several of these challenges, including those related to sampling (e.g., defining appropriate comparison groups), measurement and clinical implications (e.g., addressing the needs of infants suspected of having early signs). We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations.
Lonnie Zwaigenbaum; Audrey Thurm; Wendy Stone; Grace Baranek; Susan Bryson; Jana Iverson; Alice Kau; Ami Klin; Cathy Lord; Rebecca Landa; Sally Rogers; Marian Sigman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  37     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-11-13     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-80     Citation Subset:  IM    
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MeSH Terms
Autistic Disorder / diagnosis*
Child Development
Data Collection
Early Diagnosis
Mass Screening / methods
Prospective Studies
Research Design
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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