| Studying DNA translocation in nanocapillaries using single molecule fluorescence. | |
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MedLine Citation:
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PMID: 23284180 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We demonstrate simultaneous measurements of DNA translocation into glass nanopores using ionic current detection and fluorescent imaging. We verify the correspondence between the passage of a single DNA molecule through the nanopore and the accompanying characteristic ionic current blockage. By tracking the motion of individual DNA molecules in the nanocapillary perpendicular to the optical axis and using a model, we can extract an effective mobility constant for DNA in our geometry under high electric fields. |
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Authors:
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Vivek V Thacker; Sandip Ghosal; Silvia Hernández-Ainsa; Nicholas A W Bell; Ulrich F Keyser |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-30 |
Journal Detail:
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Title: Applied physics letters Volume: 101 ISSN: 0003-6951 ISO Abbreviation: Appl Phys Lett Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9881183 Medline TA: Appl Phys Lett Country: - |
Other Details:
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Languages: ENG Pagination: 223704 Citation Subset: - |
Affiliation:
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Cavendish Laboratory, University of Cambridge, JJ Thompson Avenue, Cambridge CB3 0HE, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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