| Study of visceral hypersensitivity in irritable bowel syndrome. | |
| | |
MedLine Citation:
|
PMID: 15612244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Visceral hypersensitivity is highly prevalent in most functional bowel disorders, such as irritable bowel syndrome (IBS), and activation of intestinal mast cells (MC) may play a role because they have been found in close proximity to gastrointestinal mucosal sensory nerve terminals containing neuropeptides and a bi-directional pathway connecting the central nervous system, gut, and MC has been demonstrated. The current study appraised the status of rectal visceral perception, as well as the changes in the MC and substance P (SP) in the intestinal mucosa of patients with IBS. METHODS: The study group comprised 42 patients with IBS and 19 healthy subjects who underwent anorectal manometry and rectal perception thresholds to balloon distension. The MC and the SP-ergic terminals in the mucosa were stained for respective histochemical and immunohistochemical investigations. The results were presented both qualitatively and quantitatively by color image analyzer, based on analysis of the intensity and area of stained fibrils. The structural relationship between the MC and nerve terminals was studied by electron microscopy, using an in situ embedding technique. RESULTS: The anorectal resting pressure, squeezing pressure and relaxation pressure were normal in both groups. The sensation threshold, defecation threshold and pain threshold in diarrhea-predominant IBS and the pain thresholds in constipation-predominant IBS were much lower than in the controls. Rectal compliance decreased in IBS. The number of MC in the terminal ileum, the ileocecal junction and the ascending colon was significantly elevated in IBS (P < 0.01), and the MC showed great variation. A significantly increased concentration of SP was found in the colon of the IBS patients compared with the controls. There was a positive correlation between the profiles of mucosal MC and the SP-ergic terminals, and MC were closely adjacent to SP-ergic terminals in the lamina propria. CONCLUSION: As altered rectal perception is present in almost all patients with IBS, it might be a reliable biological characteristic of the disease. Alterations in the MC and SP of the intestinal mucosa may be important factors in visceral hypersensitivity. |
| | |
Authors:
|
Wen Zhu Dong; Duo Wu Zou; Zhao Shen Li; Xiao Ping Zou; Ai Yong Zhu; Guo Ming Xu; Ning Yin; Yan Fang Gong; Zhen Xing Sun; Xiao Hua Man |
Related Documents
:
|
1124344 - Effect of two methylated prostaglandin e2 analogs on gastroduodenal pressure in man. 8588414 - Intraoperative esophageal manometry and fundoplications: prospective study. 1872404 - Contraction and accommodation of guinea pig duodenum in vitro. 10752874 - Suppression of uninhibited rectal detrusor by functional magnetic stimulation of sacral... 8961074 - Moexipril versus captopril in patients with mild to moderate hypertension. 1124344 - Effect of two methylated prostaglandin e2 analogs on gastroduodenal pressure in man. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chinese journal of digestive diseases Volume: 5 ISSN: 1443-9611 ISO Abbreviation: Chin J Dig Dis Publication Date: 2004 |
Date Detail:
|
Created Date: 2004-12-22 Completed Date: 2005-01-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101088612 Medline TA: Chin J Dig Dis Country: Australia |
Other Details:
|
Languages: eng Pagination: 103-9 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China. wzhdong@yahoo.com.cn |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Defecation Female Humans Intestinal Mucosa / physiology Irritable Bowel Syndrome / physiopathology* Male Mast Cells / physiology Middle Aged Pain Threshold Perception* Pressure Rectum / innervation, physiology* Substance P / analysis |
| Chemical | |
Reg. No./Substance:
|
33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Categorization of dysmotility in patients with chronic constipation and its significance for managem...
Next Document: Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trinitr...