| Study of uranium transfer across the blood-brain barrier. | |
| | |
MedLine Citation:
|
PMID: 14526964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Uranium is a heavy metal which, following accidental exposure, may potentially be deposited in human tissues and target organs, the kidneys and bones. A few published studies have described the distribution of this element after chronic exposure and one of them has demonstrated an accumulation in the brain. In the present study, using inductively coupled plasma mass spectrometry (ICP-MS) for the quantification of uranium, uranium transfer across the blood-brain barrier (BBB) has been assessed using the in situ brain perfusion technique in the rat. For this purpose, a physiological buffered bicarbonate saline at pH 7.4 containing natural uranium at a given concentration was perfused. After checking the integrity of the BBB during the perfusion, the background measurement of uranium in control rats without uranium in the perfusate was determined. The quantity of uranium in the exposed rat hemisphere, which appeared to be significantly higher than that in the control rats, was measured. Finally, the possible transfer of the perfused uranium not only in the vascular space but also in the brain parenchyma is discussed. |
| | |
Authors:
|
V Lemercier; X Millot; E Ansoborlo; F Ménétrier; A Flüry-Hérard; Ch Rousselle; J M Scherrmann |
Related Documents
:
|
7752844 - Uptake and distribution of exogenous coq in the mitochondrial fraction of perfused rat ... 4079444 - Perfusion of the isolated rat hind limb. an analysis of the technique. 523774 - Elimination of allopurinol by the perfused rat liver preparation. 651014 - Effects of intracerebroventricular prostaglandins e2 and f2alpha on the urine outflow, ... 4899874 - Interferon synthesis in x-irradiated animals. iv. donor-type serum interferons in rat-t... 11566294 - Detection of 1,n2-propanodeoxyguanosine adducts of trans-4-hydroxy-2-nonenal after gava... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Radiation protection dosimetry Volume: 105 ISSN: 0144-8420 ISO Abbreviation: Radiat Prot Dosimetry Publication Date: 2003 |
Date Detail:
|
Created Date: 2003-10-06 Completed Date: 2003-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8109958 Medline TA: Radiat Prot Dosimetry Country: England |
Other Details:
|
Languages: eng Pagination: 243-5 Citation Subset: IM |
Affiliation:
|
INSERM-U26, Hôpital Fernand Widal, 75475 Paris Cedex 10, France. valerie.lemercier@voila.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood-Brain Barrier / physiology* Brain / blood supply*, metabolism* Cerebrovascular Circulation / physiology Injections, Intra-Arterial Male Mass Spectrometry / methods Radiation Dosage Radiometry / methods* Rats Rats, Sprague-Dawley Tissue Distribution Uranium / administration & dosage*, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
|
7440-61-1/Uranium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sensitivity analysis techniques applied to a revised model of molybdenum biokinetics.
Next Document: Uncertainties on the committed equivalent dose to the thyroid as a function of age for different iod...