| Study of total stimulated saliva flow and hyperpigmentation in the oral mucosa of patients diagnosed with hereditary hemochromatosis. Series of 25 cases. | |
| | |
MedLine Citation:
|
PMID: 22157666 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: To study lesions in the oral cavity of patients with hereditary hemochromatosis and determine their association with iron overload. Study Design: We took a clinical history, examined the pigmentation of the oral mucosa, and measured total stimulated saliva production. We correlated our results with epidemiological, phenotypic, and genotypic findings. Patients with associated diseases or drug therapy causing xerostomia were excluded. Results: We evaluated 25 patients (20 men, mean age 52 years) over a period of 6 months. No patient complained of xerostomia and pigmentation was not detected in the oral mucosa. The total stimulated salivary flow was reduced in 9 patients who had an average ferritin level of 796.5 µg/l. The decline in total stimulated salivary flow was significantly correlated with ferritin levels (p=0.002). Patients with ferritin levels within the normal range also had normal stimulated salivary flow. Conclusions: We found no pigmented lesions in the oral mucosa; however, we did observe a decrease in total stimulated salivary flow that correlated with ferritin levels. Therefore, hyposialia caused by functional impairment of the salivary glands may be an early marker of iron deposition. |
| | |
Authors:
|
M-A Sánchez-Pablo; V González-García; A Del Castillo-Rueda |
Related Documents
:
|
10394476 - An mri study of adolescent patients with either schizophrenia or bipolar disorder as co... 18486106 - Altered metabolic integrity of corpus callosum among individuals at ultra high risk of ... 11120436 - The prevalence and stability of an executive processing deficit, response inhibition, i... 9109186 - Auditory evoked potentials, clinical vs. research applications. 10659486 - Idiopathic hypoparathyroidism and celiac disease in two patients with previous history ... 16259066 - The significance of bladder trabeculation in the female lower urinary system: an object... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
|
Title: Medicina oral, patologia oral y cirugia bucal Volume: - ISSN: 1698-6946 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101231694 Medline TA: Med Oral Patol Oral Cir Bucal Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Internal Medicine Department, Hospital General Universitario Gregorio Marañón, C / Dr Esquerdo, 46, 28007 Madrid, Spain, miguelangelsanchezpablo@hotmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased TNF-?, IL-6 and decreased IL-1? immunohistochemical expression by the stromal spindle-shap...
Next Document: Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH anti...