| Study on the specificity of fibronectin for post-mortem diagnosis of early myocardial infarction. | |
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MedLine Citation:
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PMID: 12201064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the specificity of fibronectin (Fn) in the post-mortem diagnosis of myocardial infarction, the changes of Fn staining in normal, infarcted and other non-infarcted myocardial injuries resulting from myocarditis, mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion and organophosphate poisoning were studied with an immunohistochemistry and image analysis system. The results showed that positive Fn staining could only be observed in groups of myocardial infarction and myocarditis, but could not be found in groups of mechanical asphyxia, electrocution, hemorrhagic shock, cardiac contusion, and organophosphate poisoning. Our findings indicate that positive staining of Fn in cardiomyocytes could be affected only by myocarditis, so it is quite specific for the diagnosis of myocardial infarction. |
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Authors:
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Bing-Jie Hu; Yu-Chuan Chen; Jia-Zhen Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine, science, and the law Volume: 42 ISSN: 0025-8024 ISO Abbreviation: Med Sci Law Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-30 Completed Date: 2002-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400721 Medline TA: Med Sci Law Country: England |
Other Details:
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Languages: eng Pagination: 195-9 Citation Subset: IM |
Affiliation:
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Department of Forensic Pathology, Faculty of Forensic Medicine, Sun Yat-sen University of Medical Sciences, 74 Zhongshan Road II, Guangzhou, 510080, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Diagnosis, Differential Female Fibronectins / analysis* Forensic Medicine Humans Male Middle Aged Myocardial Infarction / diagnosis* Myocardium / chemistry* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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