| Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives. | |
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MedLine Citation:
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PMID: 22997710 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituentss were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid). |
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Authors:
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Chan Woo Lee; Nok Hyun Park; Jin Woong Kim; Byung Hun Um; A V Shpatov; E E Shults; I V Sorokina; S A Popov |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganicheskaia khimiia Volume: 38 ISSN: 0132-3423 ISO Abbreviation: Bioorg. Khim. Publication Date: 2012 May-Jun |
Date Detail:
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Created Date: 2012-09-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804941 Medline TA: Bioorg Khim Country: Russia (Federation) |
Other Details:
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Languages: eng Pagination: 374-81 Citation Subset: IM |
Affiliation:
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Amore-Pacific Co. R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-Do, 446-729, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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