Document Detail

Study of septic shock in the non-human primate: relationship of pathophysiological response to therapy with anti-TNF antibody.
MedLine Citation:
PMID:  7628065     Owner:  NLM     Status:  MEDLINE    
Therapy with anti-TNF antibody is reported to be effective in preventing morbidity and mortality in baboons given lethal infusions of Escherichia coli. Treated animals survived, and organ histopathology was absent when antibody was administered early after lethal infusions of E. coli. The present study explored the relationship between antibody dosage, pathophysiology, and survivability from shock. When antibody dose was decreased lungs, kidneys, adrenals, spleen, and liver were injured as shown by increased vascular congestion, hemorrhage, edema, and necrosis of tissues. Survival was also affected. All animals treated with 15 mg/kg antibody survived as reported earlier; less than 60% survived with 7.5 mg/kg; 9% survived with 5.0 mg/kg, and all died with 1.5 mg/kg. Serum concentrations of interleukin-6 (IL-6) increased markedly as dose of antibody decreased. The increases in concentrations of IL-6 were associated with increases in morbidity and mortality following E. coli administration.
L B Hinshaw; T E Emerson; A C Chang; M Duerr; G Peer; M Fournel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  44     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-09-07     Completed Date:  1995-09-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-9     Citation Subset:  IM    
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
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MeSH Terms
Adrenal Glands / pathology
Antibodies, Monoclonal / administration & dosage
Dose-Response Relationship, Immunologic
Escherichia coli Infections
Interleukin-6 / metabolism
Kidney / pathology
Liver / pathology
Lung / pathology
Shock, Septic / mortality,  pathology,  therapy*
Spleen / pathology
Survival Rate
Tumor Necrosis Factor-alpha / immunology*,  metabolism
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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