Document Detail


Study of the rostral midbrain atrophy in progressive supranuclear palsy.
MedLine Citation:
PMID:  12736089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rostral midbrain atrophy in progressive supranuclear palsy (PSP) is detected by mid-sagittal plain magnetic resonance imaging (MRI). The shape of the atrophy looks like the bill of a hummingbird (hummingbird sign). We studied this sign to elucidate the nature of midbrain atrophy in PSP. Eight patients with PSP, 12 with Parkinson's disease (PD), and 10 normal controls were studied. Using mid-sagittal plain MRI, we measured the rostral and caudal midbrain tegmentum (MT), superior and inferior colliculus, pontine base, and tegmentum. We compared the length of the interpeduncular fossa, which is posterior to the mammillary body, to the diameter of the midbrain tegmentum. The multiple comparison method was used for the statistical analysis. The hummingbird sign was demonstrated in all of the PSP patients studied, and it was not observed in PD patients nor in normal controls. The hummingbird sign in the PSP patients was due to the atrophy of the midbrain tegmentum (rostral and caudal) and to a relative increase in the length of the interpeduncular fossa over that of the anteroposterior diameter of the midbrain tegmentum. The hummingbird sign, which represents the atrophy of the rostral midbrain tegmentum, strongly suggests the involvement of the rostral interstitial nucleus of the medial longitudinal fasciculus in patients with PSP. Demonstration of a hummingbird sign on MRI is thought to be useful for a diagnosis of PSP.
Authors:
Naoko Kato; Kimihito Arai; Takamichi Hattori
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  210     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-08     Completed Date:  2003-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Affiliation:
Department of Neurology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. HZD02371@nifty.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Atrophy / etiology,  pathology*
Female
Humans
Magnetic Resonance Imaging / methods
Male
Mesencephalon / pathology
Middle Aged
Parkinson Disease / pathology
Supranuclear Palsy, Progressive / complications,  pathology*
Tegmentum Mesencephali / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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