| Study on the role of environmental parameters and HIF-1A gene polymorphism in coronary collateral formation among patients with ischemic heart disease. | |
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MedLine Citation:
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PMID: 21945026 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD. DESIGN AND METHODS: Patients with ≥70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). RESULTS: There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR=1.026, 95%, CI: 1.02-0.04, p<0.001), whereas aging and cigarette smoking were negative predictors (OR=0.95, 95% CI: 0.91-0.99, p<0.05; OR=0.30, 95% CI: 0.11-0.79, p <0.05; respectively). CONCLUSIONS: The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia. |
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Authors:
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Mohammad Alidoosti; Mahboobeh Ghaedi; Abbas Soleimani; Salar Bakhtiyari; Mehrnaz Rezvanfard; Shekufeh Golkhu; Narges Mohammadtaghvaei |
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Publication Detail:
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Type: - Date: 2011-9-16 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Interventional Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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