| Study on the relationship between calcium-induced calcium release from mitochondria and PTP opening. | |
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MedLine Citation:
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PMID: 11129955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The permeability transition pore (PTP) is central for mitochondria function. PTP either open in low-conductance state to carry out mCICR (Ca2+-induced Ca2+ release from mitochondria) and play roles in cell phsyiological activities or open in high-conductance conformation to release harmful substances and play important roles in cell pathological responses and apoptosis. The results of study on the relationship between mCICR and PTP opening show Ca2+ concentrations but not the Ca2+ delivery mode determined the occurrence of mCICR or PTP opening. Ca2+-induced PTP opening began with and depended on mCICR. mCICR was a prerequisite for H2O2 and As2O3-induced PTP opening. The results indicated that the PTP opening was determined by Ca2+ stimulation intensity but not mode. PTP could switch from low- to high-conductance conformation and the PTP open by high-conductance began with low-conductance state. mCICR is necessary for Ca2+-dependent PTP opening. Our data suggested also that it would be possible to control cellular responses first by modulating mCICR, then by regulating PTP opening. |
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Authors:
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X Huang; D Zhai; Y Huang |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 213 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-20 Completed Date: 2001-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 29-35 Citation Subset: IM |
Affiliation:
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National Laboratory of Biomacromolecules, Institute of Biophysics, Academia Sinica, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism* Female Fluorescence Intracellular Membranes / metabolism, physiology* Membrane Potentials Mitochondria, Liver / metabolism, physiology* Permeability Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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