Document Detail


Study on pulmonary, prostatic and renal (medulla and cortex) distribution of sagamicin at different time intervals.
MedLine Citation:
PMID:  3583487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to assess the therapeutic activity of an antibiotic, not only its serum kinetics but also its kinetics in the peripheral tissues must be determined, thus evaluating the specific power of penetration of the drug. Sagamicin is an aminoglycosidic basic antibiotic closely related to gentamicin and its penetration rate into lungs, kidney and prostate, together with its serum concentrations time-course, were investigated. The findings obtained showed that this antibiotic attained a good distribution in the peripheral tissues, where it easily reached therapeutic levels.
Authors:
F Fraschini; P C Braga; F Scaglione; A Zanollo; P Politi; R Odero; R Trazzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  7     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-29     Completed Date:  1987-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoglycosides / blood,  metabolism,  urine
Anti-Bacterial Agents / blood,  metabolism*,  urine
Half-Life
Humans
Injections, Intramuscular
Kidney Cortex / metabolism*
Kidney Medulla / metabolism*
Lung / metabolism*
Male
Prostate / metabolism*
Time Factors
Chemical
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 52093-21-7/micronomicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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