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Study of the protective Mechanisms of compound Danshen tablet (Fufang Danshen Pian) against myocardial ischemia/reperfusion injury via the Akt-eNOS signaling pathway in rats.
MedLine Citation:
PMID:  25178948     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Danshen Tablet (CDT), an herbal preparation consisting of Salvia miltiorrhiza (Radix and rhizome of Salvia miltiorrhiza Bge.), Notoginseng (Radix and rhizome of Panax notoginseng (Burk.) F. H. Chen) and Borneolum Syntheticum, is widely used to improve coronary heart disease, cardiac angina and atherosclerosis in clinic in Asia and Pacific Ocean area, especially in China.
AIM: The study is to research the protective mechanisms of Compound Danshen Tablet (CDT) against myocardial ischemia/reperfusion (MI/R) injury via the Akt-eNOS signaling Pathway in rats.
MATERIALS AND METHODS: Rats were randomized into 7 groups: Sham group; Model group; Low-Dose CDT group (0.315g/kg/d, i.g); Middle-Dose CDT group (0.63g/kg/d, i.g); High-Dose CDT group (1.26g/kg/d, i.g); Compound Danshen Dripping Pills (CDDP) group (0.0945g/kg/d, i.g); Sulfotanshinone Sodium Injection (Tan II A) group (5mg/kg/d, i.m). After the administration, the hearts of the rats were subjected to 30min of coronary artery occlusion and 2h of reperfusion except the Sham group rats.
RESULTS: CDT significantly decreased infarct size, apoptosis, caspase-3 protein expression, MDA level in myocardial tissues, the activities of serum CK, LDH and cTnI; on the contrary, it increased p-Akt, p-eNOS, bcl-2 protein expression, the activities of SOD and tissue LDH, and the level of NO.
CONCLUSIONS: CDT can protect cardiomyocytes against MI/R injury and inhibits apoptosis in rats by activating Akt-eNOS signaling pathway.
Authors:
Qin Ren-An; Lin Juan; Li Chuyuan; Fu Wenjuan; Huang Chunyan; Yu Xuemei; Huang Lin; Nie Hong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-29
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  -     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ireland Ltd.
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