| Study of pro-thrombotic and pro-inflammatory factors in Chagas cardiomyopathy. | |
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MedLine Citation:
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PMID: 21109919 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: The relationship between inflammatory and prothrombotic activity in chagas cardiomyopathy and in other etiologies is unclear. OBJECTIVE: To study the profile of pro-thrombotic and pro-inflammatory markers in patients with Chagas' heart failure and compare them with patients of non-chagas etiology. METHODS: Cross-sectional cohort. Inclusion criteria: left ventricle ejection fraction (LVEF) < 45% and onset time to symptoms > one month. The patients were divided into two groups: group 1 (G1) - seropositive for Chagas - and group 2 (G2) - seronegative for Chagas. Pro-inflammatory factor: Ultra-sensitive CRP. Pro-thrombotic factors: thrombin-antithrombin factor, fibrinogen, von Willebrand factor antigen, plasma P-selectin and thromboelastography. Sample calculated for 80% power, assuming a standard deviation difference of 1/3; significant p if it is < 0.05. Statistical analysis: Fisher's exact test for categorical variables; unpaired Student's t-test for parametric continuous variables and Mann-Whitney test for nonparametric continuous variables. RESULTS: Between January and June 2008, 150 patients were included, 80 in G1 and 70 in G2. Both groups maintained the averages of high sensitivity CRP above baseline values, however, there was no significant difference (p = 0.328). The fibrinogen levels were higher in G2 than in G1 (p = 0.015). Among the thromboelastography variables, the parameters MA (p=0.0013), G (p=0.0012) and TG (p =0.0005) were greater in G2 than in G1. CONCLUSION: There is no evidence of greater pro-thrombotic status among patients with Chagas disease. The levels of fibrinogen and the MA, G and TG parameters of the thromboelastography point to pro-thrombotic status among non-chagas patients. Both groups had increased inflammatory activity. |
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Authors:
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Leila Maria Magalhães Pessoa de Melo; Germano Emílio Conceição Souza; Leandro Richa Valim; Luiz Felipe Pinho Moreira; Elbio Antonio Damico; Tania Rubia Flores da Rocha; Antonio Carlos Pereira Barretto; Celia Maria Cassaro Strunz; Edimar Alcides Bocchi; José Antonio Franchini Ramires |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-12 |
Journal Detail:
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Title: Arquivos brasileiros de cardiologia Volume: 95 ISSN: 1678-4170 ISO Abbreviation: Arq. Bras. Cardiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 655-62 Citation Subset: IM |
Affiliation:
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Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, USP. |
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