Document Detail


Study of potential mechanisms of traumatic rupture of the aorta using insitu experiments.
MedLine Citation:
PMID:  17311167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Traumatic rupture of the aorta (TRA) is an important transportation-related injury. This study investigated TRA mechanisms using in situ human cadaver experiments. Four quasi-static tests and one dynamic test were performed. The quasi-static experiments were conducted by perturbing the mediastinal structures of the cadavers. The mechanisms investigated included anterior, superior, and lateral displacement of the heart and aortic arch. The resulting injuries ranged from partial tears to complete transections. All injuries occurred within the peri-isthmic region. Intimal tears were associated with the primary injuries. The average failure load and stretch were 148 N and 30 percent for the quasi-static tests. This study illustrates that TRA can result from appropriate application of nominal levels of longitudinal load and tension. The results demonstrate that intraluminal pressure and whole-body acceleration are not required for TRA to occur. The results suggest that the role of the ligamentum arteriosum is likely limited, and that TRA can occur in the absence of pulmonary artery injury. Tethering of the descending thoracic aorta by the parietal pleura is a principal aspect of this injury.
Authors:
Warren N Hardy; Chirag S Shah; James M Kopacz; King H Yang; Chris A Van Ee; Richard Morgan; Kennerly Digges
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Stapp car crash journal     Volume:  50     ISSN:  1532-8546     ISO Abbreviation:  Stapp Car Crash J     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-02-21     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101133951     Medline TA:  Stapp Car Crash J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-66     Citation Subset:  IM    
Affiliation:
Wayne State University, Detroit, MI 4820, USA. whardy@wayne.edu
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MeSH Terms
Descriptor/Qualifier:
Acceleration*
Accidents, Traffic*
Adult
Aged
Anisotropy
Aorta / physiology*
Aortic Rupture / etiology*,  physiopathology*
Cadaver
Computer Simulation
Elasticity
Female
Humans
Male
Middle Aged
Models, Cardiovascular*
Physical Stimulation / adverse effects*
Stress, Mechanical
Tensile Strength

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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