| Study of platelet-activating factor acetylhydrolase in the perioperative period of patients undergoing cardiac surgery. | |
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MedLine Citation:
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PMID: 9617879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After operations with cardiopulmonary bypass, patients often show early symptoms of the systemic inflammatory response syndrome (SIRS). Potential mediators of SIRS include the platelet-activating factor (PAF), which has been linked to septic shock and multiple organ dysfunction. We studied the effect of cardiac surgery on PAF acetylhydrolase, the PAF-degrading plasma enzyme, as well as the relationship between the enzyme and the postoperative state of the patients. PAF acetylhydrolase activity decreased by 38+/-8% after instituting cardiopulmonary bypass because of plasma dilution and returned to near-preoperative levels within 6 h postsurgery. After that, enzyme levels decreased again, resulting in a 24+/-12% reduction until at least 3 days postsurgery. Patients in poor postoperative condition (Acute Physiology Score >9) had a lower preoperative PAF acetylhydrolase activity than did normal patients (12+/-4 vs. 17+/-4 nmol min(-1) mL(-1); p < .05). Likewise, patients who developed postoperative SIRS had a lower preoperative PAF acetylhydrolase activity than did patients without SIRS (12+/-3 vs. 17+/-4 nmol min(-1) mL(-1); p < .05). The data suggest that PAF acetylhydrolase deficiency is among the factors associated with postoperative distress after cardiac surgery. |
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Authors:
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M Schlame; A B Schmid; R Haupt; B Rüstow; W J Kox |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 9 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-31 Completed Date: 1998-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 313-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Therapy, University Hospital Charité, Humboldt University, Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Alkyl-2-acetylglycerophosphocholine Esterase Adult Aged Aged, 80 and over Analysis of Variance Apolipoproteins A / blood Apolipoproteins B / blood Cardiac Surgical Procedures* Cardiopulmonary Bypass* Cholesterol / blood Female Humans Male Middle Aged Phospholipases A / blood* Postoperative Period Reference Values Regression Analysis |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Apolipoproteins B; 57-88-5/Cholesterol; EC 3.1.1.-/Phospholipases A; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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