Document Detail


Study on the pharmacokinetics and metabolism of paeonol in rats treated with pure paeonol and an herbal preparation containing paeonol by using HPLC-DAD-MS method.
MedLine Citation:
PMID:  18215489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paeonol, a principal bioactive component of the Chinese herb Moutan Cortex with anti-inflammatory and analgesic effects, was comparatively studied to determine its pharmacokinetic behavior and metabolic profile in rat following oral administration of the pure paeonol alone and an herbal preparation "Qingfu Guanjieshu" (QFGJS) containing paeonol. An HPLC-DAD method was developed and validated for determining the concentration of paeonol in rat plasma. The in vivo time curves and AUC of paeonol at three doses were increased in a dose-dependent manner, while the pharmacokinetic parameters of paeonol in QFGJS at a comparable dosage were significantly elevated in comparison with those of pure paeonol. By using LC-Q/TOF-MS technique, four metabolites of paeonol were identified in plasma at 5min after dosing, with T(max) around 20min after treatment with the pure paeonol or QFGJS. Interestingly, relative concentrations of metabolites P2, P3 and P5 were markedly increased in plasma of rats treated with QFGJS compared with those of pure paeonol. These results indicate that other components in QFGJS could effectively influence the pharmacokinetic behavior and metabolic profile of paeonol in rats. The current studies emphasize the significance of the research toward an understanding of pharmacokinetic interactions of the co-existing components in the herbal preparations.
Authors:
Ying Xie; Hua Zhou; Yuen-Fan Wong; Hong-Xi Xu; Zhi-Hong Jiang; Liang Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-05
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  46     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  748-56     Citation Subset:  IM    
Affiliation:
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
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MeSH Terms
Descriptor/Qualifier:
Acetophenones / analysis,  metabolism,  pharmacokinetics*
Animals
Calibration
Chromatography, High Pressure Liquid / methods*
Drug Stability
Drugs, Chinese Herbal / analysis,  metabolism,  pharmacokinetics*
Male
Quality Control
Rats
Rats, Sprague-Dawley
Spectrometry, Mass, Electrospray Ionization / methods*
Chemical
Reg. No./Substance:
0/Acetophenones; 0/Drugs, Chinese Herbal; 0/qingfu guanjieshu; 552-41-0/paeonol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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