Document Detail

Study of oral, ear, nose and throat involvement in pemphigus vulgaris by endoscopic examination.
MedLine Citation:
PMID:  22716123     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pemphigus vulgaris (PV) is an autoimmune blistering skin disorder characterized by the presence of suprabasal acantholysis and autoantibodies against desmoglein 3. There are two different clinical forms: mucocutaneous (MCPV) and mucosal (MPV). However, little is known about PV lesions in oral, ear, nose and throat (OENT) areas produced by the very dynamic of the anatomical structures involved in the functions of the aerodigestive tract.
OBJECTIVES: To investigate the pattern of OENT manifestations in PV, and their relationship with physiological traumatic mechanisms in stratified squamous epithelial structures.
METHODS: A prospective analysis of 40 patients diagnosed with MCPV (22 patients) or MPV (18 patients) was carried out at the University Clinic of Navarra. OENT manifestations were evaluated in all patients endoscopically. OENT involvement was divided into anatomical areas.
RESULTS: The most frequent symptom was pain, mainly on oral mucosa (87·5%). Buccal mucosa (90%), posterior wall of pharynx (67·5%), upper edge of epiglottis (85%) and nasal vestibule (70%) were the areas most frequently affected in the OENT mucosa. These localizations were related to physiological traumatic mechanisms in polystratified squamous epithelial structures.
CONCLUSIONS: OENT endoscopy should be included in the examination of all patients with PV. Knowledge of the most frequent localizations of active lesions on OENT mucosa in PV will help us to interpret more efficiently the findings from OENT endoscopy. Also, information related to traumatic physiological mechanisms on OENT areas must be offered to patients in order to avoid the appearance of new active PV lesions.
S Fernández; A España; M Navedo; L Barona
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  167     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-30     Completed Date:  2013-04-11     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1011-6     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. BJD © 2012 British Association of Dermatologists.
Department of Otorhinolaryngology, Unit of Autoimmune Blistering Skin Diseases, University Clinic of Navarra, School of Medicine, PO Box 4209, Pamplona 31080, Navarra, Spain.
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MeSH Terms
Azathioprine / therapeutic use
Drug Therapy, Combination
Ear Diseases / diagnosis*,  drug therapy
Endoscopy / methods*
Glucocorticoids / therapeutic use
Immunosuppressive Agents / therapeutic use
Middle Aged
Mouth Diseases / diagnosis*,  drug therapy
Mycophenolic Acid / analogs & derivatives,  therapeutic use
Nose Diseases / diagnosis*,  drug therapy
Pemphigus / diagnosis*,  drug therapy
Pharyngeal Diseases / diagnosis*,  drug therapy
Prospective Studies
Severity of Illness Index
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid; 446-86-6/Azathioprine; 9242ECW6R0/mycophenolate mofetil

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