| Study of oligoclonal bands restricted to the cerebrospinal fluid in multiple sclerosis patients in the city of São Paulo. | |
| | |
MedLine Citation:
|
PMID: 20069212 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) varies widely in different populations. The objective of this study was to determine the frequency of these OCB in a group of MS patients in the city of São Paulo. Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting. Oligoclonal bands were found in 49 (54.4%) out of 90 patients with clinically definite MS; in (31.2%) of the 16 patients with clinically isolated syndrome; in 7 (17.9%) of 39 patients with inflammatory disorders of the central nervous system (IDCNS), and in none of the individuals with no neurological condition (control group). The specificity of the method was 100% when compared to the control group and 82.1% when compared to the IDCNS group. These results suggest that the frequency of CSF OCB is much lower in Brazilian MS patients from São Paulo city than that reported in MS series from Caucasian populations. |
| | |
Authors:
|
Paulo Diniz da Gama; Luís Dos Ramos Machado; José Antonio Livramento; Hélio Rodrigues Gomes; Tarso Adoni; Angelina Maria Martins Lino; Paulo Eurípedes Marchiori; Rogério de Rizo Morales; Marco Aurélio Lana-Peixoto; Dagoberto Callegaro |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arquivos de neuro-psiquiatria Volume: 67 ISSN: 1678-4227 ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-01-13 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
|
Languages: eng Pagination: 1017-22 Citation Subset: IM |
Affiliation:
|
Department of Neurology and Neurosurgery, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. inst.cerebro@globo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Case-Control Studies Cohort Studies Female Humans Immunoblotting Isoelectric Focusing Male Multiple Sclerosis / cerebrospinal fluid*, diagnosis Oligoclonal Bands / cerebrospinal fluid* Predictive Value of Tests Reference Values Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Oligoclonal Bands |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Physical exercise in rats with epilepsy is protective against seizures: evidence of animal studies.
Next Document: Clinical behavior of Streptococcus pneumoniae meningoencephalitis.