| Study of a novel ultrasonically triggered drug vehicle with magnetic resonance properties. | |
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MedLine Citation:
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PMID: 20854938 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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We developed a novel ultrasonically triggered drug vehicle with magnetic resonance (MR) properties by encapsulating superparamagnetic iron oxide (SPIO) nanoparticles in hydroxyapatite (HA)-coated liposomes. The effects of HA coating on the background leakage, ultrasound response and MR signal were investigated. HA coating of liposomes significantly reduced the background leakage of liposome. It also enhanced their sensitivity to ultrasound regardless of HA thickness or ultrasound frequency, even under sonication conditions of high frequency (1 and 3 MHz) and low power density (0.2-0.4 Wcm(-2)) used for diagnosis. However, it was found that the ultrasonically triggered vehicle could exhibit T(2) contrast in MR images by encapsulating SPIO. However, HA coating reduced the r(2) value of SPIO encapsulated in liposomes, but had no significant effect on the r(2)(∗) value, implying that MR images of HA-coated liposomes encapsulating SPIO could be probed by the T(2)(∗) signal. Most importantly, the r(2)(∗)-r(2) value of HA-coated liposomes encapsulating SPIO decreased after sonication, suggesting that the proposed vehicle could be used not only as a MR-guided drug vehicle capable of ultrasonically triggered release but also as a MR reporter to probe ultrasonic triggering. |
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Authors:
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Tse-Ying Liu; Hsin-Hui Huang; Yen-Ju Chen; Yu-Jen Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-18 |
Journal Detail:
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Title: Acta biomaterialia Volume: 7 ISSN: 1878-7568 ISO Abbreviation: Acta Biomater Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
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Languages: eng Pagination: 578-84 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Biomedical Engineering, National Yang-Ming University, 155, Sec. 2, Lih-Nong Street, Taipei, Taiwan, ROC. andyliudpum@yahoo.com.tw |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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