Document Detail

Study of the minimum inhibiting concentration of a new cephalosporin (HR 756): comparative data with other beta-lactamic antibiotics
MedLine Citation:
PMID:  6272823     Owner:  NLM     Status:  MEDLINE    
HR 756 is a new beta-lactamase resistant cephalosporin. The activity of HR 756 was compared in vitro to that of cefamandole, cefoxitine, cefuroxime and cephalothin. A concentration of 1 microgram/ml inhibited practically all isolates of E. coli, Salmonella, Shigella, Proteus indole + and indole --, Klebsiella, etc. A lower activity in vitro has been found regarding to Enterobacter, Serratia, Citrobacter and Pasteurella. The cefotaxime has some anti-Pseudomonas activity at concentrations of 7.5-15 micrograms/ml. For most Gram-negative organisms, HR 756 was most active. The cephalothin and the cefoxitine have resulted more active regard to Staph. aureus and Bacteroides fragilis, respectively.
M T Mascellino; G Prignano; F Iegri; S Delia
Publication Detail:
Type:  Comparative Study; English Abstract; Journal Article    
Journal Detail:
Title:  Bollettino dell'Istituto sieroterapico milanese     Volume:  60     ISSN:  0021-2547     ISO Abbreviation:  Boll Ist Sieroter Milan     Publication Date:  1981 May 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  17720040R     Medline TA:  Boll Ist Sieroter Milan     Country:  ITALY    
Other Details:
Languages:  ita     Pagination:  102-9     Citation Subset:  IM    
Vernacular Title:
Studio sulla minima concentrazione inibente di una nuova cefalosporina (HR 756): dati comparativi con altri antibiotici beta-lattamici.
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MeSH Terms
Bacteria / drug effects*
Cefamandole / pharmacology
Cefotaxime / administration & dosage,  pharmacology*
Cefoxitin / pharmacology
Cefuroxime / pharmacology
Cephalothin / pharmacology
Reg. No./Substance:
153-61-7/Cephalothin; 34444-01-4/Cefamandole; 35607-66-0/Cefoxitin; 55268-75-2/Cefuroxime; 63527-52-6/Cefotaxime

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