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A STUDY OF THE LOW BLOOD PRESSURES ASSOCIATED WITH ANAPHYLACTIC AND PEPTONE SHOCK AND EXPERIMENTAL FAT EMBOLISM, WITH SPECIAL. REFERENCE TO SURGICAL SHOCK.
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MedLine Citation:
PMID:  19868225     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
1. In peptone shock there is a marked, precipitate fall in arterial pressure. At the same time there is a fall in venous pressure. 2. In experimental fat embolism, (a) the fall in blood pressure is always gradual; (b) approximately 1 cc. of oil for each pound of body weight must be injected before a lasting fall in arterial pressure is produced; (c) it makes only a slight difference whether this amount is injected in small doses at a time or in relatively large quantities; and (d) when the arterial pressure falls, but not till then, the venous pressure rises. 3. In peptone shock, dyspnea, by its suction and force-pump action upon the reservoir of stagnating blood in the liver, brings more blood to the heart and causes a rise in arterial pressure. By repeatedly inducing short periods of dyspnea at frequent intervals, permanently beneficial results are obtained and the life of the animal can be saved. 4. In experimental fat embolism, dyspnea will cause a rise in blood pressure. But permanently beneficial results have not been obtained by this method. If dyspnea is found to bring permanent improvement in surgical shock, it is indirect evidence that this condition is not due to fat embolism. Respiratory suction is probably not responsible for the rise in blood pressure in experimental fat embolism. It seems more likely that the dyspnea in some way facilitates the passage of blood through the embarrassed pulmonary circulation. Artificial respiration with a bellows will also frequently cause a rise in blood pressure in experimental fat embolism. 5. In peptone shock the respiration is usually not affected, although there is some evidence that the respiratory center may be in a state of increased irritability. In experimental fat embolism, in some animals a violent dyspnea develops spontaneously. This is usually accompanied by edema of the lungs. In other instances, an apnea occurs, even before the blood pressure has begun to decline.
Authors:
J P Simonds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  27     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1918 May 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  2010-09-27    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-61     Citation Subset:  -    
Affiliation:
Department of Pathology of Northwestern University Medical School, Chicago.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1918, by The Rockefeller Institute for Medical Research New York
Received Day: 28 Month: 11 Year: 1917
Print publication date: Day: 1 Month: 5 Year: 1918
Volume: 27 Issue: 5
First Page: 539 Last Page: 561
ID: 2125882
PubMed Id: 19868225

A STUDY OF THE LOW BLOOD PRESSURES ASSOCIATED WITH ANAPHYLACTIC AND PEPTONE SHOCK AND EXPERIMENTAL FAT EMBOLISM, WITH SPECIAL. REFERENCE TO SURGICAL SHOCK
J. P. Simonds
From the Department of Pathology of Northwestern University Medical School, Chicago.


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