Document Detail

Study of intrachromosomal duplications among the eukaryote genomes.
MedLine Citation:
PMID:  11719577     Owner:  NLM     Status:  MEDLINE    
Complete eukaryote chromosomes were investigated for intrachromosomal duplications of nucleotide sequences. The analysis was performed by looking for nonexact repeats on two complete genomes, Saccharomyces cerevisiae and Caenorhabditis elegans, and four partial ones, Drosophila melanogaster, Plasmodium falciparum, Arabidopsis thaliana, and Homo sapiens. Through this analysis, we show that all eukaryote chromosomes exhibit similar characteristics for their intrachromosomal repeats, suggesting similar dynamics: many direct repeats have their two copies physically close together, and these close direct repeats are more similar and shorter than the other repeats. On the contrary, there are almost no close inverted repeats. These results support a model for the dynamics of duplication. This model is based on a continuous genesis of tandem repeats and implies that most of the distant and inverted repeats originate from these tandem repeats by further chromosomal rearrangements (insertions, inversions, and deletions). Remnants of these predicted rearrangements have been brought out through fine analysis of the chromosome sequence. Despite these dynamics, shared by all eukaryotes, each genome exhibits its own style of intrachromosomal duplication: the density of repeated elements is similar in all chromosomes issued from the same genome, but is different between species. This density was further related to the relative rates of duplication, deletion, and mutation proper to each species. One should notice that the density of repeats in the X chromosome of C. elegans is much lower than in the autosomes of that organism, suggesting that the exchange between homologous chromosomes is important in the duplication process.
G Achaz; P Netter; E Coissac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular biology and evolution     Volume:  18     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2280-8     Citation Subset:  IM    
Structure et Dynamique des Génomes, Institut Jacques Monod, Paris, France.
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MeSH Terms
Arabidopsis / genetics
Caenorhabditis elegans / genetics
Chromosomes / genetics
Data Interpretation, Statistical
Drosophila melanogaster / genetics
Gene Duplication*
Models, Genetic
Plasmodium falciparum / genetics
Repetitive Sequences, Nucleic Acid*
Saccharomyces cerevisiae / genetics

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